Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents |
| |
Authors: | V Chel H A H Wijnhoven J H Smit M Ooms P Lips |
| |
Institution: | (1) Verpleeghuis Marienhave, Warmond, The Netherlands;(2) EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands;(3) Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands;(4) Department of Endocrinology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands |
| |
Abstract: | Summary The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared
in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly
dose was the least effective.
Introduction It is assumed that equivalent daily, weekly or monthly doses of vitamin D3 equally influence vitamin D status. This was investigated
in a randomized clinical trial in nursing home residents.
Methods The study was performed in ten nursing homes including 338 subjects (76 male and 262 female), with a mean age of 84 (± SD
6.3 years). They received oral vitamin D3 either 600 IU/day, or 4200 IU/week, or 18,000 IU/month or placebo. After 4 months,
calcium was added during 2 weeks, 320 mg/day or 640 mg/day or placebo. Outcome: serum levels of 25-hydroxyvitamin D (25(OH)D),
parathyroid hormone (PTH) and bone turnover markers. Statistical approach: linear multilevel analysis.
Results At baseline, mean serum 25(OH)D was 25.0 nmol/L (SD 10.9), and in 98%, it was lower than 50 nmol/L. After 4 months, mean serum
25(OH)D levels increased to 62.5 nmol/L (after daily vitamin D3 69.9 nmol/L, weekly 67.2 nmol/L and monthly 53.1 nmol/L, P < 0.001 between groups). Median serum PTH levels decreased by 23% (p < 0.001). Bone turnover markers did not decrease. Calcium supplementation had no effect on serum PTH and bone turnover.
Conclusion Daily vitamin D was more effective than weekly, and monthly administration was the least effective. |
| |
Keywords: | Calcium supplementation Secondary hyperparathyroidism Vitamin D deficiency Vitamin D supplementation |
本文献已被 SpringerLink 等数据库收录! |
|