特异性免疫对儿童支气管哮喘血清白细胞介素4、白细胞介素18和转化生长因子β1水平的影响

目的 观察特异性免疫对儿童支气管哮喘血清白细胞介素4 （IL-4）、白细胞介素18（IL-18）和转化生长因子β1（TGF-β1）水平的影响.方法 将75例支气管哮喘患儿按随机数字表法分为观察组38例和对照组37例.对照组给予药物治疗,观察组在对照组的基础上给予特异性免疫治疗,治疗12个月后比较两组患儿第1秒用力呼气容积（FEV1）、FEV1/用力肺活量（FVC）、FVC、呼气峰流速（PEF）等肺功能指标及血清IL-4、IL-18和TGF-β1水平,并比较不同治疗效果患儿血清IL-4、IL-18和TGF-β1水平.结果 治疗12个月后,观察组患儿FEV1、FEV1/FVC、FVC和PEF肺功能指标分别为（2.82±0.35）L、（81.65±5.38）％、（3.46±0.45）L和（5.61±1.44） L/s,对照组分别为（2.17±0.29）L、（72.84±4.82）％、（3.24±0.41）L和（5.08±1.35） L/s,两组比较差异有统计学意义（P＜0.05）;观察组患儿血清IL-4、IL-18和TGF-β 1水平分别为（5.94±4.76） ng/L、（192.85±54.06）ng/L和（6.17±0.42）μg/L,对照组分别为（7.26 ±5.33） ng/L、（259.61±67.83） ng/L和（6.83±0.48）μg/L,两组比较差异有统计学意义（P＜0.05）;不同治疗效果患儿血清IL-4、IL-18和TGF-β1水平差异有统计学意义（P＜0.05）.结论 IL-4、IL-18和TGF-β1均参与支气管哮喘患儿的炎性反应,检测血清IL-4、IL-18和TGF-β1水平能够为儿童支气管哮喘的治疗和预后判断提供依据.

Effect of specific immunotherapy on serum interleukin-4, interleukin-18 and transforming growth factor-betal for the treatment of bronchial asthma in children

Objective To observe the effect of specific immunotherapy on serum interleukin-4 （IL-4）,interleukin-18 （IL-18） and transforming growth factor-beta 1 （TGF-β 1） for the treatment of bronchial asthma in children.Methods Seventy-five patients with bronchial asthma in children were divided into observation group（38 cases） and control group（37 cases） by random digits table method.The control group was received drug treatment,the observation group was given specific immunotherapy on the basis of the control group.After 12 months of treatment,the level of forced expiratory volume in 1 second （FEV1）,FEV1/forced vital capacity （FVC）,FVC,peak expiratory flow （PEF） such as lung function and serum IL-4,IL-18 and TGF-β1 between two groups was compared and the level of serum IL-4,IL-18 and TGF-β1 was compared among different efficacy.Results After 12 months of treatment,the level of FEV1,FEV/FVC,FVC,PEF was （2.82 ± 0.35） L,（81.65 ± 5.38）%,（3.46 ± 0.45） L,（5.61 ± 1.44） L/s in observation group,（2.17 ±0.29） L,（72.84 ±4.82）%,（3.24 ±0.41） L,（5.08 ± 1.35） L/s in control group,and there was significant difference （P 〈 0.05）.After 12 months of treatment,the level of serum IL-4,IL-18 and TGF-β1 was （5.94 ± 4.76） ng/L,（192.85 ± 54.06） ng/L,（6.17 ± 0.42） μ g/L in observation group,（7.26 ± 5.33） ng/L,（259.61 ± 67.83） ng/L,（6.83 ± 0.48） μ g/L in control group,and there was significant difference（P 〈 0.05）.There was significant difference in the level of serum IL-4,IL-18 and TGF-β1 among different efficacy（P 〈 0.05）.Conclusion IL-4,IL-18 and TGF-β 1 in children with bronchial asthma are involved in the inflammatory response,serum IL-4,IL-18 and TGF-β1 levels can provide the basis for the treatment and prognosis of bronchial asthma in children.