左乙拉西坦对部分性癫痫患者认知功能及情绪影响的研究

目的 探讨左乙拉西坦对部分性癫痫患者认知功能及情绪的影响.方法 将62例部分性癫痫患者按随机数字表法分为卡马西平组（30例）和左乙拉西坦组（32例）,卡马西平组给予卡马西平治疗,左乙拉西坦组给予左乙拉西坦治疗,两组于治疗前及治疗第4,8,12,16周采用蒙特利尔认知评估量表（MoCA）、焦虑自评量表（SAS）和抑郁自评量表（SDS）进行评估.结果 两组治疗前和治疗第4周MoCA评分比较差异无统计学意义（P＞0.05）;左乙拉西坦组治疗第8,12,16周MoCA评分优于卡马西平组（22.6±2.1）分比（20.8±2.6）分、（23.5±2.7）分比（21.3±2.8）分、（24.6±4.7）分比（21.2±3.0）分],差异有统计学意义（P＜0.05）.两组治疗前后SAS评分、SDS评分比较差异无统计学意义（P＞0.05）.结论 在部分性癫痫患者的药物治疗过程中,左乙拉西坦对患者认知功能的改善优于卡马西平,但对情绪的改善不明显.

The clinical study about levetiracetam on cognitive function and emotional influence in the patients with partial epilepsy

Objective To investigate the clinical influence about levetiracetam on cognitive function and emotional influence in the patients with partial epilepsy.Methods A total of 62 patients with partial epilepsy were divided into carbamazepine group （30 cases） and levetiracetam group （32 cases） by random digits table method,carbamazepine group was treated by carbamazepine while levetiracetam group was treated by levetiracetam.The patients were assessed before treatment and 4,8,12,16 weeks after treatment by the Montreal cognitive assessment scale （MoCA）,self rating anxiety scale （SAS） and self rating depression scale （SDS）.Results There was no significant difference in MoCA score between two groups before treatment and 4 weeks after treatment （P ＞ 0.05）.MoCA score at 8,12,16 weeks after treatment in levetiracetam group was better than that in carbamazepine group （22.6 ± 2.1） scores vs.（20.8 ± 2.6） scores,（23.5±2.7） scoresvs.（21.3± 2.8） scores,（24.6±4.7） scoresvs.（21.2±3.0） scores],the difference was statistically significant （P ＜ 0.05）.There was no significant difference between SAS score,SDS score between two groups before and after treatment （P ＞ 0.05）.Conclusion In the process of treating the patients with partial epilepsy by drug,levetiracetam is superior to carbamazepine on the improvement of cognitive function,but the mood improvement is not obvious.