代谢综合征患者可溶性P-选择素、氧化型低密度脂蛋白与颈动脉粥样硬化的相关性

目的 探讨代谢综合征（MS）患者血清氧化型低密度脂蛋白（Ox-LDL）和可溶性P-选择素（SP-S）与颈动脉粥样硬化（CA）的关系及临床意义.方法 入选103例MS患者和44例健康体检者（对照组）,MS患者中具有3项MS诊断条件者为低危组（51例）,具有≥4项MS诊断条件者为高危组（52例）.所有入选者应用彩色多普勒超声仪测定颈动脉内膜-中层厚度（IMT）和斑块,应用酶联免疫吸附法测定血清Ox-LDL、SP-S,并进行Pearson直线相关和二分类非条件Logistic回归分析.结果 低危组和高危组Ox-LDL、SP-S、颈动脉IMT明显高于对照组（36.42±7.17） μg/L和（54.44±8.10）μg/L）比（30.08±7.15） μg/L、（71.46±12.52）μg/L和（89.33±20.28）μg/L比（49.95±12.49） μg/L、（0.86±0.11） mm和（1.00±0.10） mm比（0.69±0.11） mm],差异有统计学意义（P＜0.01）.高危组和低危组斑块发生率明显高于对照组55.8％（29/52）和45.1％（23/51）比15.9％（7/44）],差异有统计学意义（P＜0.01）.Pearson直线相关分析结果显示,Ox-LDL与SP-S呈明显正相关（P＜0.01）.结论 随着MS诊断条件的增加,血清Ox-LDL和SP-S升高,颈动脉IMT增厚,斑块发生率升高.血清Ox-LDL与SP-S呈明显正相关.

Study on the correlation between oxidized low density lipoprotein and soluble P-selectin and carotid atherosclerosis in metabolic syndrome patients and carotid atherosclerosis

Objective To explore the relationship and clinical significance between the serum levels of oxidized low density lipoprotein （Ox-LDL） and soluble P-selectin （SP-S）,and carotid atherosclerosis （CA） in metabolic syndrome （MS） patients.Methods In 103 cases of MS patients and 44 healthy subjects （control group）,in MS patients with 3 MS diagnostic criteria for the low risk group （51 cases）,with ≥ 4 MS diagnostic criteria for high risk group （52 cases）.Carotid artery intima-media thickness （IMT） and plaque was measured by color Doppler ultrasound,serum Ox-LDL,SP-S was determined by enzyme linked immunosorbent assay,and pearson regression analysis of linear correlation and classification of two non condition Logistic was performed.Results The serum levels of Ox-LDL,SP-S,carotid artery IMT in low risk group and high risk group were higher than those in control group （36.42 ±7.17） μg/L and （54.44± 8.10） μg/Lvs.（30.08±7.15） μg/L,（71.46± 12.52） μ g/Land （89.33±20.28） μg/Lvs.（49.95 ± 12.49） μ g/L,（0.86 ± 0.11） mm and （1.00 ± 0.10） mm vs.（0.69 ± 0.11） mm],the difference was statistically significant （P ＜ 0.01）.The incidence of plaque in high-risk group and low-risk group was significantly higher than that in control group 55.8％ （29/52） and 45.1％ （23/51） vs.15.9％ （7/44）],the difference was statistically significant （P ＜ 0.01）.Linear correlation analysis results of Pearson display,Ox-LDL was positively correlated with SP-S （P ＜0.01）.Conclusion Serum Ox-LDL and SP-S are independent risk factor for carotid atherosclerosis in MS patients,they can evaluate progression of carotid atherosclerosis in patients with MS.