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| 聚乳酸-羟基乙酸共聚物吗啡微球的制备及体外释放模型的建立 | |
| 引用本文： | 张旭辉,孙永海,张宏. 聚乳酸-羟基乙酸共聚物吗啡微球的制备及体外释放模型的建立[J]. 军医进修学院学报, 2009, 30(2): 128-129 |
| 作者姓名： | 张旭辉 孙永海 张宏 |
| 作者单位： | 解放军总医院麻醉手术中心,北京,100853 |
| 基金项目： | 军队医药卫生科研基金 |
| 摘 要： | 目的：研究以聚乳酸-羟基乙酸共聚物（PLGA）为载体的吗啡生物可降解缓释微球制剂的制备，并测定其体外释放曲线，建立体外释放模型。方法：采用溶剂挥发法制备吗啡PLGA微球，高效液相色谱法（HPLC）检测微球中吗啡的含量。采用透析释药法测定微球体外释放曲线，并用零级动力学方程、一级动力学方程、Higuchi模型方程进行线性拟合。结果：吗啡PLGA微球的载药量为11．86％，药物包封产率为33％，体外释放曲线显示吗啡PLGA微球释放时间明显延长至10d以上。结论：吗啡PLGA微球明显地延长了吗啡释放时间，缓释性好，体外释放遵从零级释放模型。 |
| 关 键 词： | 吗啡 缓释制剂 聚乳酸-羟基乙酸共聚物 |
Preparation of polyactic-coglycolic acid morphine microspheres and establishment of its in vitro releasing model |
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| ZHANG Xu-hui,SUN Yong-hai,ZHANG Hong. Preparation of polyactic-coglycolic acid morphine microspheres and establishment of its in vitro releasing model[J]. Academic Journal of Pla Postgraduate Medical School, 2009, 30(2): 128-129 | |
| Authors: | ZHANG Xu-hui SUN Yong-hai ZHANG Hong |
| Affiliation: | Anesthesia and Operation center;Chinese PLA General Hospital;Beijing 100853;China |
| Abstract: | Objective:To study the preparation of polyactic-coglycolic acid(PLGA)morphine microspheres and establish its in vitro releasing model.Methods:PLGA morphine microspheres were prepared using the emulsify-solvent evaporation method and observed under a super-microscope.Drug content in morphine microspheres was detected by high performance liquid chromatography(HPLC).Dialysis method was used to examine the in vitro drug release.The release data fit three model equations.Results:The drug content in morphine micr... |
| Keywords: | morphine sustained-release preparations polyactic-coglycolic acid |
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