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| 新加良附方对移植性人胃癌抑制效应研究 | |
| 引用本文： | 董青,李春,马成杰,陈信义. 新加良附方对移植性人胃癌抑制效应研究[J]. 北京中医药大学学报(中医临床版), 2008, 15(1): 14-16 |
| 作者姓名： | 董青 李春 马成杰 陈信义 |
| 作者单位： | 1. 北京中医药大学东直门医院肿瘤血液科,北京,100700 2. 中国医学科学院肿瘤研究所 3. 北京中医药大学东直门医院肿瘤血液科,北京,100700;北京中医药大学东直门医院中医内科学教育部重点实验室,北京市重点实验室 |
| 摘 要： | 目的观察新加良附方对移植性人胃癌抑制效应。方法人源胃癌细胞系（BGC-823）经传代培养后,通过BALB/C-nu裸鼠移植制造肿瘤模型,以5-氟尿嘧啶和不同剂量的新加良附方浸膏进行干预性治疗,用抑瘤率评价新加良附方对BGC-823移植瘤生长的抑制作用。结果5-氟尿嘧啶组及新加良附方大、中、小剂量组的肿瘤抑制率分别为54.2%、54.3%、36.8%和23.3%;5-氟尿嘧啶组及新加良附方大剂量组与模型组瘤重比较,有统计学意义（P〈0.05）。结论新加良附方大剂量组对BGC-823有明显抑制作用。 |
| 关 键 词： | 新加良附方 人胃癌细胞系 肿瘤抑制率 |
| 收稿时间： | 2007-12-21 |
| 修稿时间： | 2007-12-21 |
Inhibitory effect of Xinjialiangfu Formula on transplantation human gastric cancer |
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| DONG Qing,LI Chun,MA Cheng-jie,CHEN Xin-yi. Inhibitory effect of Xinjialiangfu Formula on transplantation human gastric cancer[J]. Journal of Beijing University of Traditional Chinese Medicine, 2008, 15(1): 14-16 | |
| Authors: | DONG Qing LI Chun MA Cheng-jie CHEN Xin-yi |
| Affiliation: | DONG Qing, LI Chun, MA Cheng-jie, CHEN Xin-yi (1 Department of Oncology and Heamatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700; 2Oncology Institute, Chinese Academy of Medical Sciences; 3 Key Laboratory of Chinese Internal Medicine of Beijing and Educational Ministry, Dongzhimen Hospital, Beijing University of Chinese Medicine) |
| Abstract: | Objective To observe the inhibitory effect of Xinjialiangfu Formula on transplantation human gastric cancer. Methods After culturing and propagating BGC-823 of human gastric cancer was implanted to BALB/C-nu mice to establish the tumor model, which then was treated interferingly with 5-fluorouracil (5-FU) and different doses of Xinjialiangfu Formula. The inhibitory effect of Xinjialiangfu Formula on BGC-823 was evaluated by the tumor inhibitory rate. Results The tumor inhibitory rates of 5-FU group and different-dose Xinjialiangfu Formula groups were respectively 54.2 %, 54.3 %, 36.8 % and 23.3 %. The comparison between the model group and 5-FU group or high-dose Xinjialiangfu Formula group in tumor weight was significant statistically (P<0.05). Conclusion High-dose of Xinjialiangfu Formula has a significant inhibitory effect on BGC-823 of human gastric cancer. |
| Keywords: | Xinjialiangfu Formula cell line of human gastric cancer tumor inhibitory rate |
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