Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021 |
| |
| Affiliation: | 1. Department of General Surgery, Fifth Hospital of Wuhan, Wuhan, Hubei 430000, China;2. Department of Hepatobiliary Surgery, Renmin Hospital Hu Bei University of Medicine, Shiyan, Hubei 430000, China;3. Department of Traditional Chinese Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China;4. Department of Pharmacy, Fifth Hospital of Wuhan, Wuhan, Hubei 430000, China;5. Department of Geriatrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China |
| |
| Abstract: | BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
