Biochemical effects of a single oral dose of calcium on bone metabolism in elderly Chinese women |
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| Authors: | Jean Woo R. Swaminathan E. Lau D. MacDonald C. P. Pang B. E. C. Nordin |
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| Affiliation: | (1) Department of Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N. T., Hong Kong;(2) Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong;(3) Department of Community Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong;(4) Institute of Medical and Veterinary Science, Adelaide, Australia;(5) University of Adelaide, Adelaide, Australia |
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| Abstract: | Summary The biochemical effects of a single oral dose of 10 mmol of calcium on certain blood and urine variables were studied in 20 elderly postmenopausal subjects (mean age 72.3±6.2 years) with a very low dietary calcium intake (mean 7.2±3 mmol/day). Twelve hours after calcium administration, the plasma total calcium, phosphate and bicarbonate, and the urinary calcium/creatinine ratio rose, while the plasma parathyroid hormone and chloride, and urinary hydroxyproline/creatinine and phosphate/creatinine ratios fell. These results show that a single oral dose of calcium suppresses bone resorption in elderly women with low dietary calcium intake, and that long-term supplementation may be important in the prevention of osteoporosisrelated fractures. |
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| Keywords: | Calcium supplementation Hydroxyproline Osteoporosis Elderly |
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