| 瘢痕组织中微血管数和血管生成因子表达的研究 |
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| 引用本文： | 钱利,赵柏程,皮立,李晓芳. 瘢痕组织中微血管数和血管生成因子表达的研究[J]. 中国烧伤创疡杂志, 2003, 15(4): 285-289 |
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| 作者姓名： | 钱利 赵柏程 皮立 李晓芳 |
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| 作者单位： | 中南大学湘雅二医院烧伤整形科,湖南,长沙,410011 |
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| 摘 要： | 目的 :研究不同的瘢痕组织中血管内皮细胞生长因子 (VEGF)mRNA及其受体fms样酪氨酸激酶 - 1(Flt- 1)的表达 ,微血管 (MV)计数及其意义。方法 :应用原位分子杂交方法研究VEGFmRNA的表达 ,应用免疫组化方法研究Flt- 1表达及MV的计数。结果 :增生性瘢痕和瘢痕疙瘩组织中MV数目多于正常皮肤和扁平瘢痕组织中的MV数目。VEGFm RNA、Flt- 1在增生性瘢痕和瘢痕疙瘩中表达阳性率高于正常皮肤和扁平瘢痕组织中的表达 (P <0 0 5 ) ,VEGFmRNA表达阳性病例组的MV计数显著高于VEGFmRNA表达阴性病例组的MV计数 (P <0 0 5 )。结论 :血管内皮细胞过度增殖可能是瘢痕过度增生的重要因素之一
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| 关 键 词： | 增生性瘢痕 瘢痕疙瘩 血管内皮细胞生长因子 fms样酪氨酸激酶 微血管 |
| 文章编号： | 1001-0726(2003)04-0285-05 |
| 修稿时间： | 2003-04-16 |
A study on the expression of VEGF mRNA, Flt-1 and MV count in scar tissues |
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| QIAN Li,ZHAO Bai-cheng,PI Li,et al.. A study on the expression of VEGF mRNA, Flt-1 and MV count in scar tissues[J]. The Chinese Journal of Burns Wounds & Surface Ulcers, 2003, 15(4): 285-289 |
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| Authors: | QIAN Li ZHAO Bai-cheng PI Li et al. |
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| Affiliation: | QIAN Li,ZHAO Bai-cheng,PI Li,et al.,Dept. of Burns and Plastic Surgery,The 2nd Xiang-ya Hospital,Central South University,Changsha 410011,China |
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| Abstract: | Objective: To investigate the expression of vascular endothelial growth factor (VEGF) mRNA, fms-like tyrosine kinase (Flt-1) and microvessel (MV) count in different scar tissues. Method: The expression of VEGFmRNA was valued by in situ hybridation method and the expression of Flt-1 and MV count was investigated by using immunohistochemical method. Result: The MV count and the positive rate of VEGF mRNA, Flt-1 are higher in hyperplastic scar and keloid than those in normal skin and surgical scar. Conclusion: The proliferation of endothelial cells may initiate and stimulate the formation of pathological scars. |
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| Keywords: | Hyperplastic scar keloid vascular endothelial growth factor fms-like tyrosine kinase microvessel |
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