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Osteochondroma after Total Body Irradiation in Bone Marrow Transplant Recipients: Report of Two Cases
Authors:Maeda, Go   Yokoyama, Ryohei   Ohtomo, Katsuyuki   Takayama, Jun   Beppu, Yasuo   Fukuma, Hisatoshi   Ohira, Mutsuro
Affiliation:1 Department of Orthopedic Surgery, National Cancer Center Hospital Tokyo
2 Department of Pediatrics, National Cancer Center Hospital Tokyo
Abstract:We present two cases of osteochondroma after total body irradiationin bone marrow recipients, the first in a 6-year-old boy withjuvenile chronic myelogenous leukemia and the second in a 13-year-oldboy with acute myelogenous leukemia. The patients developedmultiple osteochondromas three years and seven years, respectively,after 12 Gy of total body irradiation. Neither had a familyhistory of hereditary multiple osteochondromatosis. A reviewof the English literature revealed only one report describingfive cases of osteochondroma after 12 Gy of total body irradiationin bone marrow transplant recipients. Osteochondroma shouldbe considered as an additional adverse effect of total bodyirradiation.
Keywords:Osteochondroma    Total body irradiation    Bone marrow transplantation
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