Osteochondroma after Total Body Irradiation in Bone Marrow Transplant Recipients: Report of Two Cases |
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| Authors: | Maeda, Go Yokoyama, Ryohei Ohtomo, Katsuyuki Takayama, Jun Beppu, Yasuo Fukuma, Hisatoshi Ohira, Mutsuro |
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| Affiliation: | 1 Department of Orthopedic Surgery, National Cancer Center Hospital Tokyo
2 Department of Pediatrics, National Cancer Center Hospital Tokyo |
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| Abstract: | We present two cases of osteochondroma after total body irradiationin bone marrow recipients, the first in a 6-year-old boy withjuvenile chronic myelogenous leukemia and the second in a 13-year-oldboy with acute myelogenous leukemia. The patients developedmultiple osteochondromas three years and seven years, respectively,after 12 Gy of total body irradiation. Neither had a familyhistory of hereditary multiple osteochondromatosis. A reviewof the English literature revealed only one report describingfive cases of osteochondroma after 12 Gy of total body irradiationin bone marrow transplant recipients. Osteochondroma shouldbe considered as an additional adverse effect of total bodyirradiation. |
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| Keywords: | Osteochondroma Total body irradiation Bone marrow transplantation |
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