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Classification of HHV-6A and HHV-6B as distinct viruses |
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| Authors: | Dharam Ablashi Henri Agut Roberto Alvarez-Lafuente Duncan A. Clark Stephen Dewhurst Dario DiLuca Louis Flamand Niza Frenkel Robert Gallo Ursula A. Gompels Per Höllsberg Steven Jacobson Mario Luppi Paolo Lusso Mauro Malnati Peter Medveczky Yasuko Mori Philip E. Pellett Joshua C. Pritchett Koichi Yamanishi Tetsushi Yoshikawa |
| Affiliation: | 1. HHV-6 Foundation, Santa Barbara, USA 2. Groupe Hospitalier Pitie-Salpetriere, UPMC Paris 06, Paris, France 3. Hospital Clinico San Carlos, Madrid, Spain 4. Barts Health NHS Trust, London, UK 5. University of Rochester Medical Center, Rochester, USA 6. University of Ferrara, Ferrara, Italy 7. Laval University, Quebec City, Canada 8. Institute for Molecular Virology, Tel Aviv University, Tel Aviv, Israel 9. Institute of Human Virology, University of Maryland School of Medicine, Baltimore, USA 10. London School of Hygiene and Tropical Medicine, University of London, London, UK 11. Aarhus University, Aarhus, Denmark 12. National Institute of Neurological Disorders and Stroke/NIH, Bethesda, USA 13. Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy 14. National Institute of Allergy and Infectious Diseases/NIH, Bethesda, USA 15. OSR Scientific Institute, Milan, Italy 16. University of South Florida, Tampa, USA 17. Kobe University Graduate School of Medicine, Osaka, Japan 18. Wayne State University School of Medicine, Detroit, USA 20. The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan 19. Fujita Health University School of Medicine, Toyoake, Japan |
| Abstract: | Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications. |
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