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Cognitive enhancing effects in young and old rats of pBC264, a selective CCKB receptor agonist |
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| Authors: | K. Taghzouti I. Léna F. Dellu B. P. Roques V. Daugé H. Simon |
| Affiliation: | Laboratoire de Physiologie Animale, Faculté des Sciences, Rabat, Morocco, MA Laboratoire de Pharmacochimie Moléculaire et Structurale, INSERM U.266, URA D1500 CNRS , Université René, Descartes (Paris V), 4 Avenue de l’Observatoire, F-75270 Paris Cedex 06, France, FR Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U.259, Université Victor Segalen Bordeaux 2, Domaine de Carreire, Rue Camille Saint-Sa?ns, F-33077 Bordeaux Cedex, France e-mail : herve.simon@bordeaux.inserm.fr, Fax : +33-5-56-96-68-93, FR |
| Abstract: | Rationale: The implication of CCKB receptors in cognitive processes is far from fully understood. Objective: The present study investigated the effect of propionyl-BC264, a selective agonist of CCKB receptors, in young and old rats. Methods: Cognitive functions were studied in a two-trial recognition memory task developed in our laboratory. Results: It was shown that propionyl-BC264 enhanced information processing in young as well as in old rats when injected (10 μg/kg; IP) immediately after the acquisition phase and before the retrieval trial but not before the acquisition trial. This cognitive enhancing effect was blocked by prior administration of L 365,260, a selective CCKB receptor antagonist. Conclusions: In view of the fact that BC264 is devoid of anxiogenic effects, it could be of value in the treatment of cognitive impairments associated with both normal and pathological ageing. Received: 4 July 1998/Final version: 19 October 1998 |
| Keywords: | BC264 Cholecystokinin CCKB receptor Memory Ageing Rat |
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