胸腺瘤与胸腺瘤合并重症肌无力的临床探讨

目的　探讨胸腺瘤 (TT)及胸腺瘤合并重症肌无力 (TTMG)的临床特点。方法　对 2 2年间外科治疗的TT 2 5 8例 ,其中单纯TT 16 8例 (组 1) ,TTMG 90例 (组 2 )的临床特点进行对比分析。结果　组 1平均年龄 38 4岁 ,93 4%的病人肿瘤直径大于 5cm ,病理分期多为III、IV期 (6 1 2 % )。组 2平均年龄 46 2岁 ,肿瘤直径 5cm以下占 6 5 6 % ,5 5 2 %为病理I期。结论　早期胸腺瘤诊断标准为 :肿瘤直径<3cm和病理分期I期 ;TTMG的特征是肌无力 (MG)的症状重、病史短、症状进展快、胸腺危象的发生率高。

Clinical study on thymomas and thymomas with myasthenia gravis

Objective: To present the clinical experience in treating thymomas and thymomas with myasthenia gravis (MG). Methods: Between 1975 to 1997, 258 patients with thymoma were surgically treated. 168 cases of thymus tumor (TT, Group I) were compared to 90 cases of thymus tumor with myasthenia gravis (TTMG, Group II). Results: In group I, the average age was 38.4 years, the youngest was 4 years old. In 93.4%, the diameter of tumors was 5cm. 61.2% were in stages III and IV of clinical pathology. In group II, the average age was 46.2 with the youngest of 20 years old, the diameter of tumor under 3cm and 5cm was 34.6% and 65.6%. 55.2% was in stage I of clinical pathology. Conclusion: Many cases of thymoma in early stage received early treatment. The diagnostic standard of thymoma in early stage is: (1) the diameter of tumor is below 3cm. (2) In stage I of clinical pathology. The clinical characteristics of TTMG are : short history, the rapid progress, serious MG symptoms, and the high incidence of thymus-crisis.