依托咪酯和丙泊酚混合液在无痛人流中的应用

目的观察依托咪酯和丙泊酚混合液在无痛人流中的麻醉效果。方法选择门诊ASAⅠ^Ⅱ级自愿接受无痛人工流产手术的患者80例,随机均分为两组(n=40)。丙泊酚组(P组)、依托咪酯和丙泊酚混合液组(EP组)。先给予舒芬太尼0.1μg/kg缓慢静注,P组静注丙泊酚(1 m L/3s)直至患者入睡(睫毛反射消失)开始手术,EP组静注依托咪酯脂肪乳与丙泊酚1∶1混合液(1 m L/3 s)(依托咪酯脂肪乳与丙泊酚按体积1∶1混合,含依托咪酯1 mg/m L及丙泊酚5 mg/m L)直至患者入睡(睫毛反射消失)开始手术,视手术时间及患者体动情况酌情追加药物2Ⅱ级自愿接受无痛人工流产手术的患者80例,随机均分为两组(n=40)。丙泊酚组(P组)、依托咪酯和丙泊酚混合液组(EP组)。先给予舒芬太尼0.1μg/kg缓慢静注,P组静注丙泊酚(1 m L/3s)直至患者入睡(睫毛反射消失)开始手术,EP组静注依托咪酯脂肪乳与丙泊酚1∶1混合液(1 m L/3 s)(依托咪酯脂肪乳与丙泊酚按体积1∶1混合,含依托咪酯1 mg/m L及丙泊酚5 mg/m L)直至患者入睡(睫毛反射消失)开始手术,视手术时间及患者体动情况酌情追加药物2³ m L,两组患者术中均予鼻导管持续吸氧(3 L/min),术中观察血压、心率、呼吸、Sp O2、麻醉效果Aldrete改良评分、到达符合离院标准的时间及满意度、眩晕、恶心呕吐、肌阵挛、注射痛、术中知晓及麻醉效果。结果两组血压、心率、呼吸、Sp O2、麻醉效果Aldrete改良评分、到达符合离院标准的时间及满意度、眩晕、恶心呕吐、肌阵挛、注射痛、术中知晓及麻醉效果差异明显。结论依托咪酯和丙泊酚混合液麻醉一种是更有效、更安全、且不良反应少的无痛人流麻醉方法。

Application of Etomidate and Propofol Mixture in Painless Artificial Abortion

Objective To observe the anesthetic effect of etomidate and propofol mixture in painless artiifcial abortion. Methods The clinic ASAⅠ-Ⅱvoluntarily accept the operation of painless artiifcial abortion in 80 cases,were randomly averagely divided into two groups （n=40）. Propofol group （group P）,etomidate and propofol mixture group （group EP）,give ifrst sulfentanil 0.1μg/kg slowly intravenous injection. Group P intravenous infusion of propofol （1 mL/3s） patients with sleep （until loss of eyelash relfex） began operation;group EP propofol and etomidate fat emulsion injection static 1∶1 mixture （1 mL/3s） （propofol and etomidate fat emulsion by volume 1∶1 mixed with 1 mg/mL etomidate and 5 mg/mL of propofol） until the patients to sleep （loss of eyelash relfex） began operation,as the operation time and patient movement where appropriate,additional drugs 2-3mL,patients in the two groups were given nasal catheter oxygen （3 L/min）,to observe intraoperative blood pressure,heart rate,respiration,SpO2,anesthesia effect in Aldrete modiifed score,to meet the awareness,anesthetic effect,standard discharging time and satisfaction,dizziness,nausea and vomiting,myoclonus,injection pain. Results Two groups of blood pressure,heart rate,respiration,SpO2,anesthesia effect in Aldrete modiifed score,standard discharging time and satisfaction,dizziness,nausea and vomiting,m yoclonus,injection pain,awareness during operation and anesthesia effect are different. Conclusion Etomidate and propofol mixture anesthesia is a better anesthesia method for painless more effective,safer,and less side effects.