先兆子痫患者血清视黄醇结合蛋白4的表达水平

目的 检测先兆子痫患者血清视黄醇结合蛋白4（RBP4）和超敏C反应蛋白（hsCRP）的水平,探讨RBP4与先兆子痫发病的关系.方法 采取先兆子痫组61例（轻度先兆子痫组31例、重度先兆子痫组30例）,正常妊娠组30例,非孕对照组30例,采用酶联免疫吸附试验等法测定其血清中RBP4和hsCRP浓度,同时测定胰岛素抵抗指数和血脂.结果 轻度和重度先兆子痫组血清RBP4均明显高于正常妊娠组和非孕对照组,差异均有统计学意义（q分别=2.24、2.46、2.61、2.83,P均＜0.05）,hsCRP水平明显高于正常妊娠组和非孕对照组,差异均有统计学意义（q分别=2.15、2.21、2.43、2.55,P均＜0.05）;重度先兆子痫组RBP4和hsCRP均明显高于轻度先兆子痫组,差异均有统计学意义（q分别=3.25、3.17,P均＜0.05）;先兆子痫孕妇血清RBP4水平与血清hsCRP和HOMA-IR呈正相关（r分别=0.42,0.38,P均＜0.05）.结论 先兆子痫患者血清RBP4水平升高,可作为临床观察指标.

Clinical significance of serum retinol binding protein 4 in preeclamptic patients

Objective To investigate the levels of serum RBP4 and hsCRP in preeclamptic patients. Methods Serum levels of RBP4 and hsCRP were measured in 31 mild preeclamptic patients, 30 severe preeclamptic patients and 30 normal pregnant women. 30 non-pregnant women were controls. HOMA-IR and blood lipid were measured. Results RBP4 levels were significantly higher in preeclamptic women than that in normal pregnant women and non-pregnant women （q=2.2g, 2.46, 2.61, 2.83, P〈0.05）;hsCRP levels were significantly higher in preeclamptic women than that in normal pregnant women and non-pregnant women （q=2.15, 2.21, 2.43, 2.55, P〈0.05）;RBP4 and hsCRP level were significantly higher in severe preeclamptic cases than that in mild preeclamptic subjects（q=3.25, 3.17, P〈0.05）;RBP4 were positively correlated with hsCRP and HOMA-IR （r=0.42,0.38,P〈0.05）. Conclusions The increased level of RBP4 can be used as the clinical observation indicator of the preeclampsia.