两种药物联合治疗70例子宫腺肌病的对比研究

[目的]探讨促性腺激素释放激素类似物(GnRHa)联合左炔诺孕酮宫内缓释系统(LNG-IUS)治疗子宫腺肌病(AM)的临床疗效。[方法]将70例AM患者随机分为观察组(n=34,GnRHa联合LNG-IUS治疗)与对照组(n=36,采用LNG-IUS治疗),比较两组患者治疗后子宫体积、痛经程度及月经过多等症状的改善情况。[结果]治疗后,子宫体积、痛经程度评分及月经量观察组明显低于或少于对照组,差异有统计学意义(P<0.05);对照组随访期间共出现7例(20.58%)阴道流血淋漓不尽,4例(11.76%)发生脱环;观察组则无阴道流血淋漓不尽情况及脱环发生。[结论] GnRHa联合LNG-IUS治疗与单纯放置LNG-IUS治疗相比,可以更有效治疗AM,缓解临床症状。

GnRHa therapy combined with Mirena for treatment of 70 cases of adenomyosis

[Objective] To investigate the clinical efficacy of gonadotropin-releasing hormone analogue (GnRHa) combined with LNG-IUS in the treatment of adenomyosis. [Methods] Seventy patients with adenomyosis were randomly divided into observation group (n=34,treated by GnRHa combined with LNG-IUS) and control group (n=36, treated by only LNG-IUS). After treatment were compared the improvement of uterine volume, dysmenorrhea and menorrhagia and other symptoms in the two groups. [Results] After treatment, the uterine volume, dysmenorrhea severity score and menstrual flow in observation group were significantly lower than those in control group(P<0.05); during follow-up time, there occurred 7 cases(20.58%) of dripping vaginal bleeding and 4 cases(11.76%) of decyclization in control group,while in observation group there was none of occurrence. [Conclusion] GnRHa combined with LNG-IUS is of better clinical efficacy in the treatment of adenomyosis than LNG-IUS used alone.