康莱特注射液在食管鳞癌患者化疗过程中的作用

目的 探讨康莱特注射液对食管鳞癌患者副反应、免疫功能和化疗疗效的影响.方法 98例食管鳞癌患者分为实验组和对照组,每组49例,对照组采用"5-氟尿嘧啶+顺铂"或"紫杉醇+顺铂"方案化疗,实验组在化疗的基础上加用康莱特注射液.结果 对照组和实验组化疗有效率差异无统计学意义(P>0.05),实验组严重消化道反应、严重骨髓抑制和乏力的发生率显著低于对照组(P<0.05).对照组和实验组化疗前后CD3+和CD8+差异无统计学意义(P>0.05).对照组化疗后CD4+T细胞百分数减少,CD4+T细胞/CD3+T细胞比值降低(P<0.05);实验组化疗后CD4+T细胞百分数增高,CD4+T细胞/CD3+T细胞比值增高(P<0.05).结论 康莱特注射液可以减轻食管鳞癌化疗的副反应,提高患者的免疫能力.

The effect of kanglaite in the chemotherapy to patients with esophageal squamous cell cancer

Objective To investigate the influence of Kanglaite injection to the curative effect,adverse reaction and immune function of patients with esophageal squamous cell cancer Methods 98 patients with esophageal squamous cell cancer were randomly divided into two groups：experimental group and control group.49 patients in control group acceptd chemotherapy with ＂5 fluorouracy and cisplatin＂ or ＂paclitaxel and cisplatin＂.70 patients in experimental group acceptd the treatment with Kanglaite injection and chemotherapy Results No apparently curative difference between two groups Incidence of serious digestive reaction and serious myeloid inhibition in experimental group was apparently lower than that in control group After chemotherapy,the percentage of CD3 ＋ T cell and CD8 ＋ T cell did not apparently modify In control group,after chemotherapy,the percentage of CD4 ＋ T cell and CD4 ＋ T /CD3 ＋ T ratio was decreased However,in experimental group,the percentage of CD4 ＋ T cell and CD4 ＋ T /CD3 ＋ T ratio was elevated after chemotherapy Conclusion Kanglarte injection can alleviate the adverse reaction which caused by chemotherapy and enhance the organism immune.