| 替比夫定对慢性乙型肝炎患者血清中IL-6和IL-18的影响 |
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| 引用本文： | 彭晓明,王煜,刘娅.替比夫定对慢性乙型肝炎患者血清中IL-6和IL-18的影响[J].中国实用医药,2011,6(13):17-18. |
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| 作者姓名： | 彭晓明 王煜 刘娅 |
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| 作者单位： | 1. 宁夏医科大学,银川,750004
2. 宁夏医科大学附属医院感染疾病科 |
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| 摘 要： | 目的 观察替比夫定(LdT)治疗前后慢性乙型肝炎(CHB)患者血清中白细胞介素 6(IL-6)和白细胞介素 18(IL-18)水平的变化,探讨替比夫定对CHB患者细胞免疫功能的影响.方法 设立健康对照组100例,CHB组96例,用ELISA方法检测各组中IL-6和IL-18的变化;CHB组加用替比夫定抗病毒治疗24周,观察治疗前后血清中IL-6、IL-18及病毒学指标的变化.结果 ①CHB患者血清中IL-6和IL-18水平较健康对照组明显升高,差异有统计学意义(P值均<0.01);②替比夫定抗病毒治疗后较治疗前血清中IL-6、IL-18及HBV DNA水平均下降,差异有统计学意义(P<0.05).结论 替比夫定通过抑制HBV复制,能够降低CHB患者血清中IL-6和IL-18的水平,可以改善CHB患者的细胞免疫功能.
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| 关 键 词： | 替比夫定 肝炎 乙型 白细胞介素6 白细胞介素18 |
Efficacy of Telbivudine for patients of chronic hepatitis B in the IL-6 and IL-18 |
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| PENG Xiao-ming,WANG Yu,LIU Ya.Efficacy of Telbivudine for patients of chronic hepatitis B in the IL-6 and IL-18[J].China Practical Medical,2011,6(13):17-18. |
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| Authors: | PENG Xiao-ming WANG Yu LIU Ya |
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| Institution: | PENG Xiao-ming,WANG Yu,LIU Ya,et al.Yinchuang Medical University of Ningxia Province,Yinchuan 750004,China |
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| Abstract: | Objective To observethe of serum interleukin 6(IL-6) and interleukin 18(IL-18) levels before and after telbivudine(LdT) treatment on patients with chronic hepatitis B,and to explore the efficacy of Telbivudine on cellular immune function in patients with CHB.Methods Establish healthy control group of 100 cases,CHB group of 96 patients.Measuring the serum IL-6 and IL-18 levels and changes in each groups by ELISA.CHB patients in the treatment group were treated with Telbivudine for 24 weeks,observed changes o... |
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| Keywords: | Telbivudine Hepatitis B IL-6 IL-18 |
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