电纺丝PLLA/HA复合纤维支架的制备及体外降解性能研究

随着组织工程和支架材料的技术发展，复合支架材料的制备成为当前研究的热点。本研究通过静电纺丝法制备了左旋聚乳酸／羟基磷灰石（PLLA／HA）复合纳米纤维膜，对纤维膜的结构形态进行分析，并研究其在与人体环境相近的磷酸盐缓冲溶液（pH7．4，37℃）中浸泡不同时间的体外降解过程。结果表明：HA纳米粒子与PLLA基体间存在化学键合，纳米粒子使纤维直径增大且表面粗糙程度增加，HA的引入抑制了PLLA降解过程中的自催化作用，减缓了PLLA的降解速度，复合纤维体系降解液的pH值在降解后期呈缓慢上升趋势。

Preparation and in vitro Degradation of PLLA/HA Composite Fiber Scaffolds by Electrospinning

The preparation of scaffolds consisted of a polymer composites with inorganic materials has received extensive attention recently in the field of tissue engineering.Electrospinning is a good method to obtain nano-scaled fibers from polymer solutions.In this paper,we successfully prepared non-woven micron-nanofiber mats of poly(l-lactic)(PLLA) and PLLA/ hydroxyapatite(HA) by electrospinning.Their structure,morphology and surface degradation behaviors were studied. The results indicated that a strong surface bonding was formed between the two components and the scaffolds had a perfect micro-cellular structure.The surface of hybrid fibers was much coarser because of the introduction of HA nanoparticles.The alkaline HA nano-particles inhibited the self-catalysis of PLLA during the degradation and slow down the degradation rates of PLLA fibers.The pH of hybrid system increased slowly after 28days degradation.