门冬氨酸鸟氨酸与乳果糖联用治疗肝性脑病43例

目的:观察门冬氨酸鸟氨酸与乳果糖联用治疗肝性脑病的临床疗效。方法:将86例肝性脑病患者随机分为治疗组和对照组各43例,对照组综合治疗,治疗组在综合治疗基础上,加门冬氨酸鸟氨酸静脉滴注,乳果糖口服或灌肠,7d为1疗程。结果:治疗组总有效率(88.4%)、降低血氨和改善肝功能明显优于对照组(P<0.05),且无明显不良反应。结论:门冬氨酸鸟氨酸与乳果糖联用治疗肝性脑病,疗效显著,无明显不良反应,是一种较好的方法。

Therapeutic effects of L-ornithine-L-aspartate and lactulose on hepatic encephalopathy

Objective：To observe the therapeutic effects of L-ornithine-L-aspartate and lactulose on hepatic encephalopathy. Methods Eighty-six patients with hepatic encephalopathy were randomly divided into therapy group （n= 43）and control group （n= 43）. Patients in the control group were treated with routine comprehensive therapy and those in the therapy group received additional intravenous administration with L- ornithine-L-aspartate, lactulose oral Liquid or enema therapy （once daily, 7days for a treatment course）. Results L-ornithine-L-aspartate significantly decreased blood ammonia and improved hepatic function （P〈0. 05）. The therapeutic effects of therapy group was better than those in the confrol group. Its general efficiency was 88. 4%, and it had no significant side effect. Conclusion Combined application of L-ornithine-L-aspartate and lactulose on hepatic encephalopathy is greatly effective and has no obvious side effect.