| 人胰腺癌组织nm23基因表达 |
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| 引用本文： | 李淑德 倪灿荣. 人胰腺癌组织nm23基因表达[J]. 第二军医大学学报, 1997, 18(5): 421-423 |
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| 作者姓名： | 李淑德 倪灿荣 |
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| 作者单位： | 第二军医大学长海医院消化内科 |
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| 摘 要： | 探讨ｎｍ２３基因表达与人胰腺癌临床生物不行之间的关系。方法；免疫组织化学与斑点杂 交法检测人胰腺癌组织ｎｍ２３蛋白与ｎｍ２３ｍＲＮＡ表达。结果；胰腺癌组织ｎｍ２３蛋白及ｎｍ２３ｍＲＮＡ表达较正常胰腺组织明显升高，而与慢性胰腺炎组织无明显差别；胰腺癌组织ｎｍ２３ｍＲＮＡ表达与ｎｍ２３蛋白表达呈正相关。
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| 关 键 词： | 胰腺肿瘤 nm23基因 免疫组织化学 基因表达 |
Expression of nm23 gene in human pancreatic adenocarcinoma |
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| Li Shude,Xu Guoming,Ni Canrong,Cai Jianming,Li Zhaoshen. Expression of nm23 gene in human pancreatic adenocarcinoma[J]. Former Academic Journal of Second Military Medical University, 1997, 18(5): 421-423 |
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| Authors: | Li Shude Xu Guoming Ni Canrong Cai Jianming Li Zhaoshen |
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| Abstract: | Objective: To explore the relationship between the expression of nm23 gene in tissues of human pancreatic adenocarcinoma and its clinicobiological behaviors. Methods: The expression of nm23 protein and nm23 mRNA was detected using the method of immunohistochemistry and dot blot. Results: The expression of both the protein and the mRNA of nm23 gene in pancreatic adenocarcinoma was higher than that of normal pancreas (P<0.05, P<0.01, respectively), and had no difference as compared with that of chronic pancreatitis. The expression of nm23 mRNA had correlation with that of nm23 protein (r= 0.95 , P<0.01).Conclusion:The results show that nm23 gene may have no function of tumor metastasis suppressor and that the high expression of nm23 mRNA is one of the important mechanisms by which the nm23 protein is overexpressed in human pancreatic adenocarcinoma. |
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| Keywords: | panceatic neoplasms nm23 gene immunohistochemistry gene expression |
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