鼻咽癌组织中COX-2和VEGF-C的表达及意义

目的探讨鼻咽癌组织中环氧合酶（COX）-2及血管内皮生长因子（VEGF）-C的表达变化及意义。方法采用免疫组化SP法检测58例鼻咽癌组织和10例正常鼻咽黏膜组织中COX-2及VEGF—C的表达，分析其与淋巴结转移的关系。结果鼻咽癌组织中COX-2、VEGF-C的阳性表达率分别为65．5％（38／58）、77．5％（45／58），显著高于正常鼻咽黏膜组织的10％（1／10）、10％（1／10），P均〈0．05；COX-2、VEGF—C的表达与鼻咽癌的淋巴结转移及分化程度相关，P均〈0．05；鼻咽癌中COX-2、VEGF—C的表达呈正相关，r=0．491，P〈0．01．结论鼻咽痛中COX-2、VEGF—C表试均增高，二者共同促进鼻咽癌的淋巴结转移。

Expression and significance of COX-2 and VEGF-C in nasopharyngeal cancer

Objective] To study the expression and significance of cyclooxygenase-2(COX-2) and vascular endothelial growth factor C(VEGF-C)in nasopharyngeal cancer(NPC).Method] The expression of COX-2 and VEGF-C in 58 NPC tissues and 10 normal nasopharyngeal tissues were evaluated by immunohistochemical analysis.Results] The positive rate of COX-2 and VEGF-C in NPC tissues was 65.5%(38/58) and 77.5%(45/58)respectively,which was significantly higher than that in normal nasopharyngeal(10%,10%,P< 0.05 respectively).The expressions of both COX-2 and VEGF-C were correlated with differentiation degree and lymph node metastasis(P< 0.05).There was a positive correlation between the expression of COX-2 and VEGFC(r=0.491,P< 0.01).Conclusion] COX-2 and VEGF-C expressions are increased in NPC,they may play an importent role in lymphnode metastasis of NPC.