| E-cad和β-cat在乳腺癌中的表达研究 |
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| 引用本文： | 曾绍文,沈金辉,吴璇.E-cad和β-cat在乳腺癌中的表达研究[J].实用医技杂志,2005,12(15):2150-2151. |
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| 作者姓名： | 曾绍文 沈金辉 吴璇 |
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| 作者单位： | 汕头市中心医院,广东,汕头,515031 |
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| 摘 要： | 目的:研究E-cad和β-cat在乳腺癌中的异常表达与病理分型、临床分期间关系。方法:应用免疫组化S-P法检测98例乳腺癌、34例乳腺活检中呈无癌组织中E-cad和β-cat中的表达情况。结果:E-cad和β-cat在乳腺癌病例中异常表达显著高于正常乳腺组织,P<0.01。E-cad和β-cat在淋巴结已转移的乳腺癌中的异常表达率显著高于未转移乳腺癌P<0.05,都存在着统计学意义。在病理分型中的异常表达差异无显著性。结论:E-cad和β-cat的表达情况可作为判断乳腺癌的生物学行为和预后的重要指标。
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| 关 键 词： | 乳腺肿瘤 E-cad β-cat 免疫组化 |
Expression and significance of E-cadherin and β-catenin in Breast Carcinoma |
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| ZENG Shao-wen,SHEN Jin-Hui,WU Xuan.Expression and significance of E-cadherin and β-catenin in Breast Carcinoma[J].Journal of Practical Medical Techniques,2005,12(15):2150-2151. |
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| Authors: | ZENG Shao-wen SHEN Jin-Hui WU Xuan |
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| Abstract: | Objective To study the expression and significance of E-cadherin and β-catenin in breast carcinoma. Methods The expression of E-cadherin and β-catenin was studied by immunohistochemical technique(S-P method)in 98 cases of breast carcinoma and 34 cases of normal breast tissue. Results The abnormal expression rate of E-cadherin and β-catenin in breast carcinoma was significant higher than that of normal breast tissue (P<0.01). E-cadherin and β-catenin abnormal expression rate of breast carcinoma with lymph node metastasis was significant higher than that of breast carcinoma without lymph node metastasis (P<0.05). Conclusion The expression of E-cadherin and β-catenin can be regarded as valuable indicators for evaluating biological behavior and the prognosis of breast carcinoma. |
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| Keywords: | E-cad |
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