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| 转铁蛋白-转铁蛋白受体在肿瘤主动靶向治疗中的应用 | |
| 引用本文： | 张莉,徐维平,苏育德,陆杨,王艳萍,汪菲,杨金敏.转铁蛋白-转铁蛋白受体在肿瘤主动靶向治疗中的应用[J].中国药业,2012,21(5):1-3. |
| 作者姓名： | 张莉 徐维平 苏育德 陆杨 王艳萍 汪菲 杨金敏 |
| 作者单位： | 1. 安徽中医学院研究生部,安徽合肥,230038 2. 安徽省立医院,安徽合肥,230001 3. 中国科学技术大学,安徽合肥,230026 |
| 摘 要： | 转铁蛋白-转铁蛋白受体介导的给药系统可以提高肿瘤细胞对药物的摄取量,降低药物毒性,提高药物的主动靶向性.该文综述了转铁蛋白和转铁蛋白受体的特点,转铁蛋白-转铁蛋白受体介导的纳米给药系统的分类,转铁蛋白-转铁蛋白受体在肿瘤疾病靶向治疗中的应用,并指出了当前转铁蛋白-转铁蛋白受体及其介导的纳米给药系统在肿瘤治疗上的不足与发展前景. |
| 关 键 词： | 转铁蛋白 转铁蛋白受体 肿瘤 纳米给药系统 |
Transferrin- Transferrin Receptor Mediated Initiative Targeted Therapy of Tumor |
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| Zhang Li , Xu Weiping , Su Yude , Lu Yang , Wang Yanping , Wang Fei , Yang Jinmin.Transferrin- Transferrin Receptor Mediated Initiative Targeted Therapy of Tumor[J].China Pharmaceuticals,2012,21(5):1-3. | |
| Authors: | Zhang Li Xu Weiping Su Yude Lu Yang Wang Yanping Wang Fei Yang Jinmin |
| Institution: | 1. Department of Postgraduates, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China 230038 ; 2. Anhui Provincial Hospital, Hefei, Anhui, China 230001 ; 3. University of Science and Technology of China, Hefei, Anhui, China 230026) |
| Abstract: | Transferrintransferrin receptor mediated drug delivery system can improve the uptake of drugs in tumor cells, reduce toxicity and improve initiative targeted activities. This review has summed up the characteristics of transferrin and transferrin receptor, the classi- fication of transferrin- transferrin receptor mediated nanodrug delivery system and transferrin-transferrin receptor in targeted tumor treatment. In addition, the current defects and prospects is indicated. |
| Keywords: | transferrin transferrin receptor tumor nano - drug delivery system |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |