硫糖铝联用黄连素治疗慢性顽固性胃炎94例

目的 探讨硫糖铝和黄连素联合应用治疗慢性顽固性胃炎的临床疗效.方法 选取2007年6月至2010年6月的慢性顽固性胃炎患者94例,改用硫糖铝和黄连素联合治疗.观察治疗前后患者幽门螺旋杆菌检测的变化、用药不良反应及治疗后的有效率.同时对所有患者随访1年,观察复发情况.结果 治疗后所有22例幽门螺旋杆茵阳性患者有16例转阴,幽门螺旋杆菌转阴率为72.73%;治疗过程中出现2例便秘,1例口干;治疗后58例痊愈,30例治疗显效,6例治疗无效,总有效率为93.62%;1年后有4例复发,1年复发率为4.26%.结论 应用硫糖铝和黄连素联合治疗慢性顽固性胃炎具有较好临床疗效,不良反应轻微,复发率低,可作为慢性顽固性胃炎的治疗手段.

Clinical Effects of Sucralfate and Berberine in Treating 94 Cases of Chronic Refractory Gastritis

Objective To explore the clinical effects of sucralfate combined with berberine in the treatment of chronic refractory gastri- tis. Methods 94 patients with chronic refractory gastritis treated in our hospital from Junuary 2007 to June 2010 were involved in this research,and sucralfate and berberine were applied in the treatment of all these patients. The change of Helicobacter pylori,adverse drug reactions and the effective rate were recorded before and after treatment. All these patients were followed up for 1 year in order to ob- serve the recurrence. Results Of 22 cases of positive Helicobacter pylori before treatment, 16 cases were converted to negative Heli- cobacter pylori after treatment,and the negative conversion rate was 72.73%. 2 cases constipated and 1 case felt thirst during treat- ment. 58 cases were totally cured,30 cases were significantly effective and 6 cases were ineffective,and the total therapeutic effective rate was 93.62%. 4 cases recurred after 1 year with the 1- year recurrence rate of 4. 26%. Conclusion Using sucralfate combined berberine in the treatment of chronic refractory gastritis could obtain better clinical effects with mild adverse reactions and low recur- rence rate,which can be used as the treatment measure to chronic refractory gastritis.