Meta-analysis of best corrected visual acuity after treatment for myopic choroidal neovascularisation |
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| Authors: | Lin Zhou Yi-Qiao Xing Tuo Li Yin Li Xiu-Sheng Song and Jia-Zhang Li |
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| Institution: | Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China;Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China;Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China;Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China;Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China;Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China;Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China;Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China |
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| Abstract: | AIMTo compare the best corrected visual acuity (BCVA) between Verteporfin with photodynamic therapy (PDT) and intravitreal anti-vascular endothelial growth factor (anti-VEGF) in patients with myopic choroidal neovascularization (CNV).METHODPublished literature from Medline, Premedline, Embase and the Cochrane Library from inception until November 2013 were retrieved. All studies evaluating the BCVA between Verteporfin with PDT and intravitreal anti-VEGF for myopic CNV were included. The results were pooled using mean difference (MD), a corresponding 95% confidence interval (CI).RESULTSFinally, five studies enrolled 349 eyes were included in the meta-analysis. We inferred that the BCVA of myopic CNV after the treatment of anti-VEGF was significantly better compared with Verteporfin with PDT (MD=0.25, 95%CI:0.17-0.33, Z=5.97, P<0.00001).CONCLUSIONThis meta-analysis suggests that intravitreal anti-VEGF could have a better BCVA after treatment than Verteporfin with PDT for myopic CNV. |
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| Keywords: | myopic choroidal neovascularization Verteporfin with photodynamic therapy anti–vascular endothelial growth factor meta-analysis |
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