单纯脑电图异常的新生儿惊厥的治疗对智能发育影响的研究

目的 研究单纯脑电图异常的新生儿惊厥患儿治疗后对智能发育的影响。方法 本研究回顾性分析武汉大学中南医院儿科2018年1月-2020年1月诊断及治疗的63例单纯脑电图异常的新生儿惊厥患儿的临床资料，其中规范性治疗30例，未治疗33例。比较治疗组与非治疗组之间惊厥发作情况和神经发育指标。结果 随访1年后，治疗组患儿的惊厥发作次数低于非治疗组（t=6.935，P<0.001）；治疗组患儿的适应性（t=9.345，P<0.001）、大运动（t=2.436，P=0.018）、精细运动（t=3.968，P<0.001）、个人社交能力（t=14.989，P<0.001）、语言能力（t=2.484，P=0.016）以及发育商（development quotient，DQ）得分（t=13.759，P<0.001）高于未治疗组。结论 及时对单纯脑电图异常的新生儿惊厥进行治疗，能够降低新生儿癫痫发作次数，对智能发育具有积极的意义。

A study on the influence of the treatment of neonatal seizures with simple electroencephalogram abnormalities on intelligence development

Objective To study the effect on mental development after treatment of neonatal convulsions in children with simple electroencephalogram abnormalities. Methods This study retrospectively analyzed the clinical data of 63 children with neonatal convulsions with simple electroencephalogram abnormalities diagnosed and treated in our hospital from January 2018 to January 2020, including 30 cases of standardized treatment and 33 cases of untreated. Convulsive seizures and neurodevelopmental indicators were compared between the treatment and non-treatment groups. Results After followed up for 1, the number of seizures in the treatment group was significantly lower than that in the non-treatment group (t=6.935, P<0.001). The adaptation (t=9.345,P<0.001), large exercise (t=2.436,P=0.018), fine motor (t=3.968,P<0.001), personal social ability (t=14.989,P<0.001), language ability(t=2.484,P=0.016), and development quotient (DQ) score in the treatment group (t=13.759,P<0.001) were significantly higher than these in the untreated group. Conclusion Timely treatment of neonatal convulsions with simple electroencephalogram abnormalities can reduce the number of neonatal seizures and has positive significance for intellectual development.