Bcl-2和Bax的表达与乳腺癌转移及预后的关系

目的　探讨Bcl 2和Bax基因在乳腺癌中的表达及与乳腺癌淋巴结转移、预后的关系。方法　应用SP免疫组化染色方法 ,检测 4 0例乳腺癌组织中Bcl 2、Bax的表达情况。结果　无淋巴结转移组Bcl 2阳性表达率与淋巴结转移组有显著差异 (P <0 .0 5 ) ,10年以上存活组Bcl 2阳性表达率与 10年以下存活组有显著差异 (P <0 .0 1)。无淋巴结转移组Bax阳性表达率与淋巴结转移组有显著差异 (P <0 .0 5 ) ,10年以上存活组Bax阳性表达率与 10年以下存活组有显著差异 (P <0 .0 5 )。结论　Bcl 2和Bax表达与乳腺癌淋巴结转移、预后关系密切 ,Bcl 2提示高表达、Bax低表达的乳腺癌患者有低的转移率及好的预后。

The relationship between expression of Bcl-2 ,Bax gene and metastasis, prognosis of breast cancer

Objective To evaluate the relation between expression of Bcl-2 and Bax gene and metastasis, prognosis of breast cancer. Methods Immunohistochemical technique was used to detect the expression of Bcl-2 and Bax gene in 40 cases of breast cancer. Results There is a remarkable difference of the positive rate of Bcl-2 between the group of negative node metastasis and the node metastasis(P<0.05),There is a remarkable difference of the positive rate of Bcl-2 between the group that have lived over 10 years and the group that have lived for less than 10 years(P<0.01).A remarkable difference of the positive rate of Bax exsited between the group of negative node metastasis and the node metastasis(P<0.05),There is a remarkable difference of the positive rate of Bax between the group that have lived over 10 years and the group that have lived for less than 10 years(P<0.05).Conclusion The expression of Bcl-2 and Bax have a closed relation with the rode metastasis and prognosis of breast cancer, which imply the patient with over expression of Bcl-2 and low expression of Bax has less metastasis and better prognosis.