| 窄谱中波紫外线对寻常型银屑病神经生长因子及其受体mRNA的影响 |
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| 引用本文： | 何荣国,田华,罗权,张燕妮,张锡宝. 窄谱中波紫外线对寻常型银屑病神经生长因子及其受体mRNA的影响[J]. 岭南皮肤性病科杂志, 2009, 16(3): 145-148 |
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| 作者姓名： | 何荣国 田华 罗权 张燕妮 张锡宝 |
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| 作者单位： | 1. 广东省广州市第十二人民医院皮肤科,广东,广州,510620
2. 广东省广州市皮肤病防治所,广东广州,510095 |
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| 摘 要： | 目的：观察窄谱中波紫外线（NB—UVB）治疗寻常型银屑病的疗效及治疗前后皮损中神经生长因子（NGF）及受体的表达。方法：用NB—UVB治疗23例寻常型银屑病患者，每周3次，连续21次，以PASI评价疗效，并以原位杂交技术和图像分析系统分析皮损部位光疗前后NGF及受体mRNA的表达情况。结果：临床总有效率为91％，光疗后PASI评分较光疗前显著降低（P〈0．001）；光疗前银屑病皮损处NGFmRNA在从基底层到颗粒层均有阳性表达，P140TrkAmRNA在表皮各层均有染色，以棘细胞层和颗粒层染色较强，P75mRNA在棘细胞层和颗粒层有较强染色；光疗后三者mRNA表达强度明显降低（P〈0．01）。结论：NB—UVB是治疗银屑病的安全有效的方法，下调皮损中NGF及受体的表达可能是NB—UVB治疗寻常型银屑病的机制之一。
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| 关 键 词： | 银屑病 窄谱中波紫外线 神经生长因子 |
Study of NB-UVB on Nerve Growth Factor and Its Receptors mRNA Expression in Psoriasis Vulgaris |
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| HE Rong-guo,TIAN Hua,LUO Quan,ZHANG Yan-ni,ZHANG Xi-bao. Study of NB-UVB on Nerve Growth Factor and Its Receptors mRNA Expression in Psoriasis Vulgaris[J]. Southern China Journal of Dermato-Venereology, 2009, 16(3): 145-148 |
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| Authors: | HE Rong-guo TIAN Hua LUO Quan ZHANG Yan-ni ZHANG Xi-bao |
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| Affiliation: | HE Rong - guo, TIAN Hua, LUO Quan, ZHANG Yan - ni, ZHANG Xi - bao ( Department of Dermatology, the 12th people＇ s Hospital, Guangzhou 510620, China) |
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| Abstract: | Objective:To investigate on the affect of NB-UVB on NGF in psoriasis vulgaris and to determine mRNA expression and its receptors(P75 and P140TrkA )in skin lesions of the patients with psoriasis vulgaris before and after NB-UVB phototherapy. Methods:A total of 23 patients with psoriasis vulgaris were treated by NB-UVB radiation 3 times per week, the study duriation in totally was 7 weeks. The severity of psoriasis was evaluated by PASI score, mRNA expression of NGF and its receptors in lesions were detected ... |
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| Keywords: | psoriasis vulgaris NB-UVB nerve growth factor |
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