Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica |
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| Authors: | Hou Chia-Chung Lin Shwu-Jiuan Cheng Juei-Tang Hsu Feng-Lin |
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| Institution: | Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, No. 250 Wu-Hsing Street, Taiwan 110, Republic of China. |
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| Abstract: | Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11beta,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity. |
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