Selectin-P and interleukin-8 plasma levels in coronary heart disease patients |
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Authors: | Romuk E Skrzep-Poloczek B Wojciechowska C Tomasik A Birkner E Wodniecki J Gabrylewicz B Ochala A Tendera M |
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Affiliation: | Department of Biochemistry, Silesian Medical University, Jordana 19 Street, PL-41-808 Zabrze, Poland. biochemz@infomed.slam.katowice.pl |
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Abstract: | BACKGROUND: Alterations of the immune system are now believed to play crucial role in the pathogenesis of atherosclerosis. The aim of this study was analysis of soluble forms of selectin-P and interleukin-8 levels in patients with different form of coronary heart disease. MATERIALS AND METHODS: In the study took part 18 patients with stable coronary heart disease, 20 patients with unstable coronary heart disease and 15 healthy persons from control group. Soluble selectin-P and interleukin-8 levels were measured in EDTA plasma with the use of enzyme immunoassay ELISA. RESULTS: The level of soluble selectin-P was significantly higher in unstable coronary heart disease patients in comparison to the stable coronary heart disease patients (P < or = 0.01) and nonsignificantly higher in comparison to the control group. The level of interleukin-8 were significantly higher in unstable coronary heart disease patients in comparison to the stable coronary heart disease patients (P < or = 0.01) and in comparison to the control group (P < or = 0.02). CONCLUSION: Our findings suggest that soluble form of selectin-P and interleukin-8 may be useful clinical predictors of unstable coronary heart disease. The assessment of the risk for the development of coronary heart disease requires further serial investigation. |
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Keywords: | Atherosclerosis coronary heart disease endothelial cells interleukin-8 soluble selectin-P |
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