Mitochondrial dysfunction and cell senescence--skin deep into mammalian aging |
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Authors: | Passos Joao F Zglinicki Thomas von |
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Institution: | Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK. |
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Abstract: | Thus, we are again left with a chicken-and egg situation: Is disrupted Ca2+ signalling, reduced mTOR activity and increased autophagy found in SOD2-/- cells because there are more senescent cells in the examined population? Or is any of these factors the culprit that triggers senescence in the first place? While the answer to these questions still eludes us, the study from Campisi and colleagues highlights the importance of mitochondrial dysfunction and cellular senescence in vivo and its impact on the aging process. |
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