| 胡颓子对人胃癌细胞增殖抑制的实验研究 |
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| 引用本文： | 林萍. 胡颓子对人胃癌细胞增殖抑制的实验研究[J]. 时珍国医国药, 2007, 18(9): 2148-2149 |
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| 作者姓名： | 林萍 |
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| 作者单位： | 湖北民族学院医学院,湖北,恩施,445000 |
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| 基金项目： | 湖北省科技攻关计划项目（No.AA301C61） |
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| 摘 要： | 目的探讨胡颓子对人胃癌SGC-7901细胞增殖抑制作用。方法wistar大鼠随机分为5组,(1)对照组:自由饮食,(2)胡颓子组:以浓度250,500,1000 mg/L胡颓子果实水煎液ig,(3)5-氟尿嘧啶(5-Fu)组:50mg/kg.wb 5-Fu ip。1周后取各组大鼠血清 RPMI-1640培养胃癌SGC-7901细胞,采用MTT法测定不同血清对胃癌SGC-7901细胞增殖的影响。结果胡颓子对胃癌细胞的增殖有显著的抑制作用(P<0.01),且抑制率随药物浓度的升高而增高,存在明显的量效关系。结论胡颓子对SGC-7901细胞增殖具有抑制作用。
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| 关 键 词： | 胡颓子 胃癌 增殖 |
| 文章编号： | 1008-0805（2007）09-2148-01 |
| 收稿时间： | 2006-12-28 |
| 修稿时间： | 2007-05-17 |
The Experimental Study of Elaeagnus on Proliferation Inhibition in Human Gastric Carcinoma Cells |
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| LIN Ping. The Experimental Study of Elaeagnus on Proliferation Inhibition in Human Gastric Carcinoma Cells[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(9): 2148-2149 |
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| Authors: | LIN Ping |
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| Affiliation: | Department of Physiology,Medical School of Hubei Institute for Nationalities, Enshi 445000, China |
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| Abstract: | Objective To detect the inhibition effect of decoction of elaeagnus on proliferation in human gastric carcinoma cell SGC-7901.Methods Gastric carcinoma cell SGC-7901 was treated with rat serum which collected from rats fed with decoction of elaeagnus or administrated with 5-fluoro-2,4 (1H,3H).Cell proliferation was assayed by MTT method.Results Elaeagnus significantly inhibited the proliferation of gastric carcinoma cells in a dose-dependent manner (p<0.01 ).Conclusion Elaeag- nus has the function of inhibiting gastric carcinoma cell proliferation. |
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| Keywords: | Elaeagnus Gastric carcinorua Proliferation |
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