心肌梗死患者同型半胱氨酸与冠心病传统危险因素的比较

为了比较包括同型半胱氨酸在内的冠心病危险因素对心肌梗死的作用，应用荧光偏振检测技术测定104名心肌梗死患者及104名对照组患者的同型半胱氨酸值，同时测定冠心病的传统危险因素，包括性别，家族史，吸烟史，高血压，糖尿病，高胆固醇血症，高甘油三酯血症，年龄，尿酸，肌苷和体重指数等。结果发现心肌梗死患者血浆同型半胱氨酸浓度显著高于对照组（P＜0．01），经多因素Logistic回归分析，吸烟史（OR＝1．066），高血压（OR＝1．128），高胆固醇血症（OR＝6．511）和同型半胱氨酸（OR＝2．875）等因素与心肌梗死的OR值有显著性，提示同型半胱氨酸与冠心病的传统危险因素相比对心肌梗死的影响较大，与心肌梗死呈较强联系。

Comparision of Homocysteine and Conventional Risk Factors in Myocardial Infarction Patients

Aim　To investigate the relationship between plasma Hcy level and conventional risk factors of CHD in MI patients.　Methods　104 cases with myocardial infaction (MI) and 104 controls were recruited to participate the study.　Plasma total Hcy were measured while subjects were fasting using fluorescence polarization immunoassays (FPIA).　Conventional risk factors of CHD such as sex, familial history, smoking, blood pressure,blood glucose,serum choleserol,serum triglycerides,age,uric acid,creatinine and quetelet index were also measured.　Results　The mean plasma Hcy level was 25.17±9.31 μmol/L for MI patients, 18.41±8. 03 μmol/L for controls.　Statistically, the mean plasma Hcy levels of MI patients were significantly higher than that of the controls(P<0.01).　By multivariate non-conditional Logistic regression analysis,the final model consists of smoking(OR=1.066), hypertension(OR=1.128),hypercholesterolemia(OR=6.511)and Hcy(OR=2.875),which have significant relation with MI.　Conclusion　Hcy has strong relation with MI.　Its OR was second compared with other conventional risk factors in MI patients by Logistic regression analysis.