| 赛庚啶对大鼠局灶性脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 梁健,胡翠兰,王美钠.赛庚啶对大鼠局灶性脑缺血再灌注损伤的保护作用[J].广州医学院学报,1997(4). |
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| 作者姓名： | 梁健 胡翠兰 王美钠 |
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| 作者单位： | 广州医学院药理教研室(梁健)，西安西北电业职工大学门诊部(胡翠兰)，西安医科大学基础医学院药理教研室(王美钠) |
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| 摘 要： | 本研究采用可逆性大鼠大脑中动物栓塞法观察赛庚啶（Cyproheptadine,Cyp）对大鼠局灶性脑缺血乔灌注后神经功能障碍、脑组织病理改变、脑水肿以及脑组织钙含量的影响。结果表明，于大脑中动物阻断前2分钟静脉注射赛庚嚷2mg，3mg．kg-1可显著减轻神经功能障碍；减轻脑水肿及脑组织病理损害，实验提示赛庚啶可能通过降低缺血再灌注引越的脑Ca2+聚集而减轻脑损伤。
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| 关 键 词： | 脑缺血 再灌注损防 神经功能障碍 钙聚集 |
Protective Effects of Cyproheptadine on Focal Brain Ischemia-Reperfusion Injury in Rats |
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| Liang Jian, et al.Protective Effects of Cyproheptadine on Focal Brain Ischemia-Reperfusion Injury in Rats[J].Academic Journal of Guangzhou Medical College,1997(4). |
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| Authors: | Liang Jian |
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| Institution: | Department of Pharmacology |
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| Abstract: | Acute cerebral ischemia-reperfusion injury was produced by reversible middle artery occlusion without craniectomy in rats. Cyprohepetadine (Cyp) 2 and 3mg iv. reduced the score of neurological deficits and the ischemia-reperfusion injury of brain tissue, and decreased the water content of injured brain. The finding showed that the drug might prevent the brain tissue from ischemia-reperfusion dmage through reducing intracellular Ca2+ accumulation resulted from ischemia and reperfusion event. |
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| Keywords: | Cerebral ischemia Reperfusion jnjury Neurological deficits Calcium accumalation |
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