Hypothalamic hamartomas and precocious puberty |
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| Authors: | M. P. Colaco M. P. Desai C. S. Choksi K. N. Shah R. U. Mehta |
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| Affiliation: | (1) Division of Pediatric Endocrinology and Department of Pediatric Medicine, Bai Jerbai Wadia Hospital for Children and Institute of Child Health, Acharya Donde Marg, Parel, 400 012 Bombay;(2) Present address: Paramount Imaging Centre, Bombay |
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| Abstract: | Ten children, five boys and five girls with true precocious puberty at an early age were found to have hypothalamic hamartomas on brain imaging. Very early onset of puberty, varying from a few weeks to three years of age, and rapid progression were characteristic. Accelerated growth velocity and markedly advanced bone age were evident in all. Gonadotropin and gonadal hormone levels were elevated above the prepubertal range. Six children had associated developmental delay or hyperactivity. |
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| Keywords: | Hypothalamic hamartoma Precocious puberty |
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