| C-erbB-2在膀胱尿路上皮细胞肿瘤中的表达及临床意义 |
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| 引用本文： | 何崇生,黄剑飞. C-erbB-2在膀胱尿路上皮细胞肿瘤中的表达及临床意义[J]. 南通医学院学报, 2006, 26(5): 325-326,330 |
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| 作者姓名： | 何崇生 黄剑飞 |
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| 作者单位： | 1. 南通大学附属医院泌尿外科,南通,226001
2. 南通大学附属医院病理科,南通,226001 |
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| 摘 要： | 目的:研究C-erbB-2在膀胱尿路上皮细胞肿瘤中的表达及临床意义。方法:采用免疫组化方法检测原发性膀胱尿路上皮细胞肿瘤87例、复发性膀胱尿路上皮细胞癌18例和膀胱非肿瘤性病变20例组织中C-erbB-2的表达。结果:C-erbB-2在膀胱病变的原发尿路上皮细胞肿瘤(47.13%)与非肿瘤性病变(10.00%)中的表达差异有统计学意义(P<0.01);且在膀胱尿路上皮乳头状肿瘤中的表达随恶性程度增高而增高(P<0.05);在原发和复发的尿路上皮细胞肿瘤中表达分别为47.13%和66.67%,两者差异无统计学意义(P>0.05)。结论:C-erbB-2在膀胱尿路上皮细胞肿瘤发生、发展中可能起重要作用,它的表达与恶性程度相关。
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| 关 键 词： | 膀胱移行细胞肿瘤 C-erbB-2 免疫组化 |
| 文章编号： | 1000-2057（2006）05-0325-02 |
| 收稿时间： | 2006-05-22 |
| 修稿时间： | 2006-05-22 |
The expression and clinical significance of C-erbB-2 in bladder urothelial tumours |
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| HE Chongsheng,HUANG Jianfei. The expression and clinical significance of C-erbB-2 in bladder urothelial tumours[J]. ACTA Academiae Medicinae Nantong, 2006, 26(5): 325-326,330 |
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| Authors: | HE Chongsheng HUANG Jianfei |
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| Affiliation: | Department of urinary surgery, the Affiliated Hospital of Nantong University, Nantong226001 ; 1 Department of pathology |
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| Abstract: | Objective:To study the clinical significance of C-erbB-2 in bladder urothelial tumour.Methods:EnVision immunohistochemisty was used to study the expressions of C-erbB-2 in nontumorous bladder tissues from 20 patients and in vesical-urothelial tumors from 105 patients.Results:The expression of C-erbB-2 in primarily vesical-urothelial tumour(47.13%)was higher than that in non-tumors bladder tissues(10.00%),with a ststistical difference between the two groups(P<0.01).The expression of C-erbB-2 in primarily bladder corpora mammillaria urothelium tumor was heightened with the advance of malignancy lever(P<0.05).Conclusion:C-erbB-2 was related to occurrence and development of bladder urothelial tumour. |
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| Keywords: | C-erbB-2 |
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