Pharmacological Induction of Fetal Hemoglobin Synthesis using Histone Deacetylase Inhibitors |
| |
| Authors: | Hua Cao |
| |
| Affiliation: | 1. Haematology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpurcsk@medic.ukm.my.;3. Haematology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur |
| |
| Abstract: | A number of pharmacological agents are currently available for the induction of the fetal hemoglobin (Hb F) to treat the patients with sickle cell disease and β-thalassemia. In the present review, we summarized the investigation and development of these Hb F-inducing agents and introduced histone deacetylase inhibitors as the new strategy to induce Hb F to treat the hemoglobin disorders |
| |
| Keywords: | Sickle cell disease β-Thalassemia Histone deacetylase inhibitor Fetal hemoglobin induction |
|
|
