Complete resolution of hepatic aspergillosis after non-myeloablative hematopoietic stem cell transplantation in a patient with acute myeloid leukemia |
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Authors: | Giuseppe Marotta Monica Tozzi Simona Sammassimo Marzia Defina Donatella Raspadori Alessandro Gozzetti |
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Affiliation: | 1. Division of Hematology and Hematopoietic Stem Cell TransplantationUniversity of Siena, Siena, Italy;2. , Email: marotta@unisi.it |
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Abstract: | Fungal infections due to Aspergillus are a frequent cause of transplant-related mortality. For this reason, leukemic patients with severe fungal infection are usually excluded from conventional allotransplantation. Recently, some authors suggested a role for non-myeloablative hematopoietic stem cell transplantation (HSCT) in this subset of patients. We used this therapeutic approach in a patient with high-risk acute myeloid leukemia in second complete remission (CR) with pre-existing hepatic aspergillosis refractory to conventional anti-fungal therapy. A complete regression of hepatic lesions was observed after 3 months from allogeneic stem cell transplantation. Our work confirms previous reports suggesting that non-myeloablative HSCT is effective in patients not eligible for conventional transplantation because of invasive aspergillosis. |
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Keywords: | ASPERGILLOSIS NON-MYELOABLATIVE HEMATOPOIETIC STEM CELL TRANSPLANTATION ACUTE MYELOID LEUKEMIA |
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