Anti-inflammatory pterocarpanoids from the roots of Pongamia pinnata |
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| Authors: | Ran Wen Hai-Ning Lv Yong Jiang |
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| Affiliation: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China |
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| Abstract: | A phytochemical study on the roots of Pongamia pinnata afforded 11 pterocarpanoids, including three new compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and HRESIMS data. The absolute configurations of the new compounds were assigned via analysis of the specific rotations and electronic circular dichroism (ECD) spectra. The isolates were evaluated for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated BV-2 microglial cells. Six compounds exhibited inhibitory effects against NO production, and compound 5 showed the best activity with an IC50 value at 12.0?μM. |
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| Keywords: | Pongamia pinnata Leguminosae pterocarpanoids anti-inflammatory effect nitric oxide inhibition |
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