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| 内皮祖细胞(EPCs)在心脏移植物血管病变(CAV)中的研究进展 | |
| 引用本文： | 胡馗,(综述)洪涛,(审校). 内皮祖细胞(EPCs)在心脏移植物血管病变(CAV)中的研究进展[J]. 复旦学报(医学版), 2013, 40(4): 491-494 |
| 作者姓名： | 胡馗 (综述)洪涛 (审校) |
| 作者单位： | 1复旦大学附属中山医院心外科上海200032; 2上海市心血管病研究所上海200032; 3上海市器官移植重点实验室上海200032 |
| 摘 要： | 内皮祖细胞(endothelial progenitor cells,EPCs)是一类能分化为成熟内皮细胞(endothelial cells,ECs)的内皮前体细胞,具有促进损伤血管修复和新生血管形成的特点。研究发现EPCs在心脏移植物血管病变(cardiac allograft vasculopathy,CAV)的发生和发展中起着重要作用,移植后供心血管内皮损伤可以触发EPCs的修复过程。本文综述了移植物血管病变的发生发展过程中EPCs的归巢和分化,探讨了EPCs对CAV的预测、诊断和治疗价值。 |
| 关 键 词： | 心脏移植物血管病变(CAV) 内皮祖细胞(EPCs) 归巢 分化 预测 治疗 |
Progress on the research ofendothelial progenitor cells (EPCs) in cardiac allograft vasculopathy (CAV) |
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| HU Kui,,HONG Tao,,. Progress on the research ofendothelial progenitor cells (EPCs) in cardiac allograft vasculopathy (CAV)[J]. Fudan University Journal of Medical Sciences, 2013, 40(4): 491-494 | |
| Authors: | HU Kui HONG Tao |
| Affiliation: | 1Department of Cardiovascular Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China; 2Shanghai Institute of Cardiovascular Disease,Shanghai 200032,China; 3Shanghai Key Laboratory of Organ Transplantation,Shanghai 200032,China |
| Abstract: | Endothelial progenitor cells (EPCs) have the ability to differentiate into mature endothelial cells (ECs).They can facilitate the repair of damaged blood vessels or augment development of new vessels.Recent data indicate that EPCs play a significant role in the occurrence and development of cardiac allograft vasculopathy (CAV).The injury of endothelium of donor heart post transplantation triggers the process of neoendothelialization.This paper reviews homing and differentiation of EPCs in the occurrence and development of allograft vasculopathy,and explore the prediction,diagnosis and therapeutic value of EPCs on CAV. |
| Keywords: | cardiac allograft vasculopathy (CAV) endothelial progenitor cells (EPCs) homing differentiation diagnosis treatment |
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