Preparative Therapies Used for those with Fanconi's Anemia Undergoing Stem Cell Transplants and Subsequent Engraftment Rates |
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Authors: | Michael E Trigg Robert Bond |
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Institution: | 1. Jefferson Medical College Thomas Jefferson University Philadelphia PA USA;2. Division of Blood and Bone Marrow TransplantationDepartment of Pediatrics A. I. duPont Hospital for Children Rockland Road 19803 Wilmington DE USA |
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Abstract: | Fanconi anemia patients are often treated with stem cell transplants to prevent myelodysplastic changes or leukemic progression. A variety of preparative regimens have been utilized. A case of a 13-year-old child with Fanconi's anemia is presented to highlight the preparative therapy utilized, engraftment rates which have been seen and the incidence of graft-vs.-host disease (GvHD). A review of the literature suggests the most successful preparative therapies with the highest engraftment rates and also suggests the best GvHD regimens. |
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Keywords: | Fanconi's anemia Engraftment rates Preparative therapy Graft-vs -host disease |
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