Antigenicity of premelanosomes and melanoma cytotoxic activity demonstrated by spleen mononuclear cells of melanoma-bearing hamster |
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| Authors: | A. TAMAKI Y. MISHIMA |
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| Affiliation: | Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki-cho 7-chome, Chuo-ku Kobe 650, Japan |
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| Abstract: | The antigenicity of premelanosomes, which are specific organelles for melanin biosynthesis in the cytoplasm of malignant melanoma cells, has been revealed by the blastogenic responses of lymphocytes from melanoma-bearing Syrian (golden) hamsters, using the lymphocyte stimula tion assay. The lymphocytes from these hamsters have also been found to exhibit cytotoxic effects on cultured melanoma cells as shown by the microcytotoxic assay technique. |
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