奥美拉唑、左氧氟沙星、阿莫西林三联法治疗消化性溃疡的疗效观察

目的评价奥美拉唑、左氧氟沙星、阿莫西林三联法治疗消化性溃疡的疗效。方法85例幽门螺杆菌（Hp）阳性消化性溃疡患者，随机分为治疗组及对照组。治疗组42例，给予奥美拉唑（20mg，2次／d）＋左氧氟沙星（200mg，2次／d）＋阿莫西林（1000mg，2次／d），疗程l周；对照组43例，给予奥美拉唑（20mg，2次／d）＋甲硝唑（400mg，2次／d）＋阿莫西林（1000mg，2次／d），疗程1周。停药4周后复查胃镜，观察Hp根除率、溃疡有效率，并观察症状缓解率及不良反应。结果治疗组Hp根除率为88．1％（37／42），对照组为62．8％（27／43）（χ^2=7．314，P〈0．叭）；治疗组和对照组症状缓解率、溃疡有效率和不良反应发生率分别为92．9％和88．4％、85．7％和72．1％、14．3％和23．3％，两组间差异无统计学意义（P〉0．05）。结论奥美拉唑、左氧氟沙星、阿莫西林三联疗法是治疗Hp阳性消化性溃疡的理想方法之一。

Triple therapy of omeprazole,levofloxacin and amoxicillin combined for peptic ulcer

Objective To evaluate the therapeutic effect of triple therapy of omeprazole, levofloxacin and amoxicillin combined for peptic ulcer. Methods 85 patients with helicobacter pylori （Hp） infection suffered from peptic ulcer were randomly divided into treatment group and control group. Treatment group （42 cases） were administrated omeprazole（20mg, twice a day） , levofloxacin（200 mg, twice a day） and amoxicillin （1000mg, twice a day） for one week; Control group（43 cases） were treated with omeprazole （20mg, twice a day） , metronidazole（400 mg, twice a day） and amoxicillin（1000 mg,twice a day） for one week. Four weeks later, The Hp eradication, ulcer effective rate, symptoms, and side-effects were observed. Results The Hp eradication rate of the treatment group was 88. 1% （37/42）, while that of the control group was 62. 8% （27/ 43）, there was significant difference between two groups （X2 = 7. 314, P 〈 0. 01 ）. The symptomatic relief rate, ulcer effective rate and side-effect rate between the treatment group and control group were 92.9% and 88. 4% , 85.7% and 72. 1% , 14. 3% and 23.3% , respectively, there was no diffierence between two groups（ P 〉 0. 05 ） . Conclusion Triple therapy of omeprazole, levofloxacin and amoxicillin combined is one of the ideal methods for Hp infection sufferred from peptic ulcer.