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Recombinant human granulocyte colony-stimulating factor induces granulocytosis in vivo |
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| Authors: | M Fujisawa Y Kobayashi T Okabe F Takaku Y Komatsu S Itoh |
| Abstract: | Recombinant human granulocyte colony-stimulating factor (G-CSF) was prepared and its granulopoietic effects on mice were examined. When mice were injected intraperitoneally with the G-CSF daily for 14 days, marked granulocytosis occurred in the mice. The number of progenitor cells (CFU-C) was remarkably increased in the spleen. The results suggest that G-CSF plays a central role in granulocyte production in vivo. |
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