缺血性脑卒中患者同型半胱氨酸水平与颈动脉粥样斑块的相关性研究

目的：探究缺血性脑卒中患者同型半胱氨酸（Hcy）水平与颈动脉粥样斑块的相关性。方法收集2012年5月至2015年7月收治的缺血性脑卒中患者560例，根据Hcy循环酶法自动分析仪检测的Hcy水平，将患者分为升高组（Hcy水平高于正常水平）及正常组（Hcy水平处于正常水平），并用超声测定两组患者颈动脉粥样斑块，最后采用控制变量和Logistic回归方法分析Hcy升高是否促进颈动脉斑块形成的发生。结果在收集的560例缺血性脑卒中患者中，升高组有330例，正常组有230例，控制变量法分析显示年龄、吸烟、体重指数（BMI）、高血压病史、血脂异常、糖尿病等会影响颈动脉粥样斑块的形成（P<0.05）。在排除其他因素影响后，Logistic回归分析结果显示，Hcy水平的升高促进颈动脉斑块发生（OR=1.91，95%CI=1.02～3.34，P=0.039）。结论缺血性脑卒中患者血浆Hcy水平增高是促进颈动脉粥样斑块形成的危险因素。

Homocysteine Levels in Patients with Cerebral Apoplexy and The Correlation of Carotid Artery Atheromatous Plaque

Objective To explore the brain of homocysteine(Hcy) levels in patients with ischemic stroke and the correlation of carotid artery atheromatous plaque.Methods Collected in May 2012 to July 2012,560 cases of patients with ischemic stroke,ac-cording to the Hcy circulating enzymatic automatic analyzer detection of Hcy levels,divided the patients into higher groups(Hcy levels higher than normal) and normal group(Hcy levels in the normal level),and ultrasonic determination of two groups of patients with carotid artery atheromatous plaque,finally USES the control variables and Logistic regression method analysis elevated homo-cysteine levels are promoting the occurrence of carotid artery plaque formation.Results In the collection of 560 cases of ischemic stroke patients,elevated group with 330 cases,normal group with 230 cases,control variable method analysis showed that age,gen-der,smoking,body mass index (BMI) and hypertension,homocysteine can affect the formation of carotid atheromatous plaque (P<0.05),Logistic regression analysis results show that after controlling for other factors,the rise of Hcy levels help carotid plaques happen (odds ratio=1.91,95% CI 1.91~3.34,P=0.039).Conclusion The increased plasma Hcy levels is a risk factor for promote carotid atheromatous plaque formation.