Valvular heart disease: undiagnosed valvular involvement, concomitant coronary artery disease and systemic embolization |
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| Authors: | D E Loew D E Harken L B Ellis |
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| Affiliation: | 1. From the Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital, Boston, Mass. U.S.A.;2. From the Thoracic Surgical Services of the Peter Bent Brigham Hospital, Boston, Mass. U.S.A.;3. From the Mount Auburn Hospital, Cambridge, Mass. U.S.A.;4. From the Departments of Medicine and Surgery, Harvard Medical School, Boston, Mass. U.S.A. |
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| Abstract: | The clinical and operative findings were correlated with postmortem findings in 259 patients who died during or shortly after open heart surgery for valvular disease. In 114 patients with clinically diagnosed isolated aortic valve disease, 72 had morphologic abnormalities of the mitral valve, and in 13 these changes were hemodynamically significant. In 28 of 81 patients with clinically diagnosed isolated mitral valve disease, 28 showed aortic valve abnormalities, but the changes were significant in only 1. Fifty-five patients showed abnormalities of the tricuspid valve. All had concomitant mitral valve disease, 44 had aortic valve disease and 2 had changes of the pulmonic valve as well. In 8 the tricuspid valve disease was hemodynamically significant; in 4 of the 8, the lesion was clinically recognized. |
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