| 六亚甲基双乙酰胺联合5-FU对涎腺粘液表皮样癌的分化诱导作用 |
| |
| 引用本文： | 贾保军,司徒镇强,吴军正,陈建元. 六亚甲基双乙酰胺联合5-FU对涎腺粘液表皮样癌的分化诱导作用[J]. 口腔颌面外科杂志, 1998, 0(2) |
| |
| 作者姓名： | 贾保军 司徒镇强 吴军正 陈建元 |
| |
| 作者单位： | 青岛海军四○一医院口腔科，西安第四军医大学口腔医学院 |
| |
| 摘 要： | 目的研究平面极性分化诱导剂六亚甲基双乙酰胺（ＨＭＢＡ）联合５ＦＵ对涎腺粘液表皮样癌的分化诱导作用。方法采用“５ＦＵ→ＨＭＢＡ”用药方案联合用药。结果ＨＭＢＡ对涎腺粘液表皮样癌有较强的分化诱导作用，当联合用药时ＨＭＢＡ的分化诱导作用被增强，另一方面，ＨＭＢＡ也明显增强了５ＦＵ的抗癌作用，两者显示出协同抗癌作用。结论将５ＦＵ与ＨＭＢＡ合用，对涎腺粘液表皮样癌的治疗可能具有一定应用价值
|
| 关 键 词： | 粘液表皮样癌 六亚甲基双乙酰胺 5-FU 诱导分化 |
DIFFERENTIATION EFFECT OF HEXAMETHYLENE BISACETAMIDE (HMBA)COMBINED WITH 5FLUOROURACIL ON MUCOEPIDERMOIDCARCINOMA IN VITRO AND IN VIVO |
| |
| Abstract: | In this study, the effects of 5Fluorouracil (5FU),in combination with HMBA on the growth and differentiation of human salivary gland carcinoma cell line MEC1 cells were investigated in vitro and in vivo. The experiments were divided into four groups; 5FU alone, HMBA alone, HMBA combined with 5FU and control group. The conclusion was as follows; HMBA can induce the MEC1 cells to differentiate toward normal or benign cells in vitro and in vivo. When HMBA was combined with 5FU, it can not only enhance 5FU cytotoxity, but also make the MEC1 cells tend to become mature. The results suggest that this combined sequential cytotoxic differentiation therapy resulting in synergistic cytotoxic and differentiation may be the basis of a new approach to cancer therapy. |
| |
| Keywords: | Differentiation inducer Mucoepidermoid carcinoma Hexamethylene Bisacetamide (HMBA) 5Fluorouracil (5FU) |
| 本文献已被 CNKI 等数据库收录！ |
