Chromophobe renal cell carcinoma |
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| Authors: | Tadao Fukushima Yoji Nagashima Yukio Nakatani Nobuko Nakarnura Kiyoshi Fukasawa Yoshiaki Satomi Ken Yu Yohei Miyagi Ichiro Aoki Kazuaki Misugi |
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| Affiliation: | Departments of Pathology, Yokohama City University, School of Medicine, Yokohama, Japan;Departments of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan;Division of Anatomic Pathology, Yokohama City University Hospital, Yokohama, Japan;Departments of Pathology, Saiseikai Yokohama City Nambu Hospital, Yokohama, Japan;Departments of Urology, Saiseikai Yokohama City Nambu Hospital, Yokohama, Japan;Department of Urology, Yokosuka Kyosai Hospital, Yokosuka, Japan |
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| Abstract: | Chromophobe renal cell carcinoma (RCC) is a recently established subtype of RCC, which has rarely been reported in Japan. In this communication, the authors report two Japanese cases of chromophobe RCC together with the immunohistochemical findings. The tumors were composed of sheets and cribriform glands formed by tumor cells with cloudy and reticular cytoplasm. Ultrastructurally, the cytoplasm was filled with numerous microvesicles. The tumor cells were positive for cytokeratin, epithelial membrane antigen, and Tamm-Horsfall protein. Occasionally, LeuM1-positive cells were also noted. Vimentin was negative, unlike the usual RCC. Reactivity for peanut agglutinin was more frequent than that to Lotus tetragonolobus agglutinin. The results of this study suggest that the tumor cellq possessed phenotypes similar to the distal nephron rather than to the proximal tubular cells. |
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| Keywords: | chromophobe renal cell carcinomay eosinophilic variant immunohistochemistry mitochondrial DNA |
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