Cyanide intoxication: protection with chlorpromazine. |
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Authors: | J L Way G Burrows |
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Institution: | 1. Department of Pharmacology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99163 USA;2. College of Pharmacy, Washington State University, Pullman, Washington 99163 USA;3. University of Idaho, Moscow, Idaho 83843 USA |
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Abstract: | Protection against cyanide intoxication in mice can be enhanced by the administration of chlorpromazine, providing it is given with sodium thiosulfate, or the sodium thiosulfate-sodium nitrite antidotal combination. Protency ratios which were derived from the LD50 values were compared in groups of mice premedicated with chlorpromazine (10 mg/kg) and/or sodium thiosulfate (1 g/kg) and/or sodium nitrite (100 mg/kg). These results indicate that the administration of chlorpromazine alone provides no protection against the lethal effects of cyanide. Chlorpromazine also does not enhance the protective effect of sodium nitrite; however, it strikingly potentiates the effectiveness of sodium thiosulfate either alone or in combination with sodium nitrite. |
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